The gold-coated filters (filtr.AID membranes with 0.8, 3, 5, and 10 µm pore sizes) are perfect substrates for ensuring both robust counting and Raman signals without substrate interference.
Standardized and computer-controlled powder dispersion pushes powders into vacuum. The particles fall slowly and are perfectly distributed on any kind of substrate.
Specifically designed to obtain perfect powerful low-noise Raman signals from aggregates and particulates in bio therapeutics.
To solve the problems, we have a novel design of a wet cell optimized for Raman spectroscopy in protein based formulations. Sampling with the wet cell preserves not only the shapes of semi-solid and even liquid particles, it also bridges from Flow Imaging (shadow counting) to scientific proof. Examples of the measurement of inherent particles, mainly protein aggregates in a highly concentrated antibody formulation demonstrate the low spectroscopic background of this wet-dispersion.AID design. With the integrated image-directed spectroscopy, we can identify silicone droplets (intrinsic particles) that give great Raman signals down to 1 µm diameter and fatty acids resulting from the hydrolysis of polysorbate. Any user will also be able to analyze larger visible particles > 80 µm easily with this setup.